Join an Important Alzheimer’s Study: Help Unlock the Link Between Brain Inflammation and Dementia

Are you or a loved one affected by Alzheimer’s or another type of dementia? Researchers are conducting a groundbreaking study to better understand how inflammation in the brain relates to Alzheimer's disease (AD), and they need your help.

This study is focused on uncovering the hidden connections between inflammation, genetics, and brain changes that occur in Alzheimer’s disease. By participating, you can contribute to critical research that may pave the way for new treatments and early detection strategies.

What Is the Alzheimer's Study About?

This research study aims to answer a big question:

How does inflammation in the brain impact the progression and symptoms of Alzheimer’s disease?

To find out, researchers are studying participants across different forms of Alzheimer’s and cognitive health, including:

• Mild Cognitive Impairment (MCI)

• Posterior Cortical Atrophy – a visual-based variant of Alzheimer’s

• Logopenic Variant Primary Progressive Aphasia – a language-focused variant

• Amnestic Alzheimer’s Disease – the typical, memory-related version

• Healthy older adults with no cognitive, language, or visual symptoms

  
  

What Will Participants Do?

Participants will undergo several safe and commonly used medical tests that help the researchers learn more about brain inflammation, including:

Brain Imaging

• PET Scans to detect inflammation using a special experimental drug called ER176

• Amyloid PET Scans using florbetaben (FDA-approved)

• Tau PET Scans using another experimental drug called MK-6240

• MRI Scans to take high-resolution pictures of brain structure

Fluid & Blood Tests

• Lumbar puncture (spinal tap) to analyze spinal fluid for inflammation-related proteins

• Blood samples to study genes related to inflammation and test for past exposure to COVID-19 (SARS-CoV-2)

Who Can Join The Alzheimer's Study?

You may be eligible if you:

• Are age 50 or older

• Have normal cognitive function OR a diagnosis of:

  • Amnestic Alzheimer’s

  • Posterior Cortical Atrophy

  • Logopenic Variant PPA

• Can speak English or Spanish

• Are able to undergo MRI and PET scans and participate in all tests

• Can provide informed consent (or have a surrogate decision maker)

  
  

Who Is Not Eligible For The Alzheimer's Study?

Unfortunately, you cannot participate if you have:

• A history of other brain disorders or stroke

• Serious medical conditions like uncontrolled epilepsy

• Contraindications to MRI (e.g., metal implants, severe claustrophobia)

• Received too much research-related radiation in the past year

Why This Study Matters

This study could revolutionize how Alzheimer’s is treated and diagnosed.By identifying how inflammation and genetics influence disease progression, doctors may one day be able to:

• Detect Alzheimer’s earlier

• Target inflammation to slow or stop disease

• Create more personalized treatment plans

How Long Is the Study?

This is a long-term study. Participants will be asked to return for follow-up testing two years later, which helps researchers track how inflammation and brain changes evolve over time.

Help Advance Alzheimer’s Research

Whether you’re living with Alzheimer’s or a healthy adult over 50, your participation can make a lasting impact. Help researchers uncover new paths to treatment and prevention in this Alzheimer's study.

See If You Qualify

Blog Disclaimer

This blog is an independent platform created to share publicly available information about ongoing research studies, primarily sourced from the official NIH (National Institutes of Health) website and other publicly accessible databases. Our goal is to hold space for individuals to explore research opportunities that may align with their interests or health profiles.

We do not work directly with the research teams or institutions conducting these studies, nor are we involved in participant selection, communication, or study oversight. All decisions regarding participation are determined solely by the research teams based on their specific study requirements and eligibility criteria.

We do not receive funding or compensation from research programs or from individuals who choose to participate. This platform is informational only and is not intended to replace professional medical advice or the official study pages.

If you choose to provide your email address, it will be used solely to share information about current or future research studies that may be of interest. Your email will never be sold, shared, or provided to research teams or third partieswithout your explicit permission.

For detailed information or to apply to a study, please contact the listed study coordinators directly through the links provided.